Table S3. IUP_list

List of 129 proteins with experimentally verified disorder status. Proteins are enlisted with their identification (Swissprot, translated EMBL or Genbank number), sequence range of disorder and reference to disorder.

All IUP sequences (129 proteins or protein fragments)

protein

Prot id.

Sequence range

reference(s)

ICAL_HUMAN

sp|P20810|

1-708

Uemori T. et al. (1990) Biochem. Biophys. Res. Commun. 166, 1485

Konno T. et al. (1997) Biochim. Biophys. Acta 1342, 73

CDNB_HUMAN

sp|P46527|

1-198

Russo, A. A. et al. (1996) Nature 382, 325-31

Verkhivker, G. M. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 5148-53

Lacy, E. R. et al. (2004) Nat. Struct. Mol. Biol. 11, 358-64

IPPD_HUMAN

sp|Q9UD71|

1-204

Uversky V. N. (2002) Prot. Sci. 11, 739-756

SECU_XELA

tr|Q9IA80|

1-188

Cox C. J. et al. (2002) FEBS Lett. 527, 303-308

Boatright K., unpublished observations

FLGM_ECOLI

sp|P43532|

1-97

Daughdrill, G. W. et al. (1997) Nat. Struct. Biol. 4, 285-91

Daughdrill, G. W. et al. (1998) Biochemistry 37, 1076-82

THYA_HUMAN

sp|P06454|

1-110

Gast, K. et al. (1995) Biochemistry 34, 13211-8

Gast, K. et al. (2003) Eur. Biophys. J. 31, 586-94

CMGA_HUMAN

sp|P10645|

19-457

Uversky V. N. (2002) Prot. Sci. 11, 739-756

SYUA_HUMAN

sp|P37840|

1-140

Weinreb, P. H. et al. (1996) Biochemistry 35, 13709-15

FNBA_STAAU

sp|P14738|

745-879

Penkett, C. J. et al. (1997) J. Mol. Biol. 274, 152-9

Penkett, C. J. et al. (1998) Biochemistry 37, 17054-67

TAU_HUMAN

sp|P10636|

1-757

Schweers, O. et al. (1994) J. Biol. Chem. 269, 24290-7

MAP2_HUMAN

sp|P11137|

1-1827

Hernandez, M. A. et al. (1986) Eur. J. Biochem. 1564, 41-8

STN1_HUMAN

sp|P16949|

1-148

Uversky V. N. (2002) Prot. Sci. 11, 739-756

CALD_HUMAN

sp|Q05682|

1-793

Lynch, W. P. et al. (1987) J. Biol. Chem. 262, 7429-37

Huber, P. A. (1997) Int. J. Biochem. Cell Biol. 29, 1047-51

Permyakov, S. E. et al. (2003) Proteins53, 855-62

OBF1_HUMAN

sp|Q16633|

1-256

Chang, J. F. et al. (1999) J. Mol. Biol. 288, 941-52

HIBN (X. laevis)

sp|P06180|

1-589

Kleinschmidt J. A. et al. (1986) Embo J. 5, 3547-3552

OSTP_HUMAN

sp|P10451|

17-314

Fisher L. W. et al. (2001) Biochem. Biophys. Res. Commun. 280, 460-465

CDNA_HUMAN

sp|P38936|

1-164

Kriwacki, R. W. et al. (1996) Proc. Natl. Acad. Sci. USA 93, 11504-9

VAM1_HUMAN

sp|P23763|

1-97

Dunker A. K. et al. (2002) Biochemistry 41, 6573

PRIO_HUMAN

sp|P04156|

23-122

Zahn C. et al. (2000) Proc. Natl. Acad. Sci. USA 97, 145-50

Donne, D. G. et al. (1997) Proc. Natl. Acad. Sci. USA 94, 13452-7

GCN4_YEAST

sp|P03069|

211-281

Van Hoy, M. et al. (1993) Cell 72, 587-94

Weiss, M. A. et al. (1990) Nature 347, 575-8

Sigler, P. B. (1988) Nature 333, 210-2

TBB1_HUMAN

sp|P07437|

398-444

Uversky V. N. (2002) Prot. Sci. 11, 739-756

EMB1_DAUCA

sp|P17639|

1-92

Eom, J. et al. (1996) Plant Sci. 115, 17-24

ATIN_HHV11

sp|P06492|

403-490

O'Hare, P. and Williams, G. (1992) Biochemistry 31, 4150-6

Sigler, P. B. (1988) Nature 333, 210-2

HtH (H. salinarum)

tr|O06022|

1-451

Uversky V. N. et al. (2000) Proteins 41, 415-427

TRIC_HUMAN

sp|P19429|

1-209

Uversky V. N. et al. (2000) Proteins 41, 415-427

GAGA_DROME

sp|Q08605|

136-519

Uversky V. N. (2002) Prot. Sci. 11, 739-756

HSP2_HUMAN

sp|P04554|

1-102

Uversky V. N. et al. (2000) Proteins 41, 415-427

H10_HUMAN

sp|P07305|

1-193

Uversky V. N. (2000) Proteins 41, 415-427

HSP3_MOUSE

sp|Q62100|

1-102

Uversky V. N. (2000) Proteins 41, 415-427

Helix destab. (P. aeruginosa)

tr|Q9I5K8|

1-144

Uversky V. N. et al. (2002) Prot. Sci. 11, 739-756

GSUB_HUMAN

sp|O96001|

1-155

Uversky V. N. et al. (2000) Proteins 41, 415-427

GELS_HUMAN

sp|P06396|

200-273

Uversky V. N. et al. (2000) Proteins 41, 415-427

EM1_WHEAT

sp|P04568|

1-93

Uversky V. N. (2002) Prot. Sci. 11, 739-756

FOS_HUMAN

sp|P01100|

216-380

Uversky V. N. (2002) Prot. Sci. 11, 739-756

TOXK_PICFA

sp|P19972|

146-222

Suzuki C. et al (1997) Prot. Eng. 10, 99-101

DAG1_MOUSE

sp|Q62165|

654-751

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

CRTC_HUMAN

sp|P27797|

18-417

Uversky V. N. (2002) Prot. Sci. 11, 739-756

SUPM_HUMAN

sp|P50224|

216-262

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

CFTR_HUMAN

sp|P13569|

708-832

Ostedgaard L. S. (2000) Proc. Natl. Acad. Sci. USA, 97, 5657-5662

NEUM_BOVIN

sp|P06836|

1-239

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

PID1_RAT

sp|P10688|

135-206

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

CIK1_HUMAN

sp|Q09470|

1-63

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

RPB1_YEAST

sp|P04050|

1436-1733

Zhang J and Corden J. L. (1991) J. Biol. Chem. 266, 2290-2296

Zhang J. and Corden J. L. (1991) J. Biol. Chem. 266, 2297-2302

Cramer P. et al. (2001) Science 292, 1863-1876

SRY_MOUSE

sp|Q05738|

144-395

Tompa, P., unpublished observations

WAS1_HUMAN

sp|Q92558|

230-311

Kim A. S. et al. (2000) Nature 404, 151-158

BN28a (B. napus)

tr|Q9FUM5|

1-65

Boothe J. G. et al. (1997) Plant Physiol. 113, 367-376

NPM3_HUMAN

sp|O75607|

1-178

Dingwall C. et al. (1987) Embo J. 6, 69-74

MPT1_HUMAN

sp|O14974|

304-512

Tóth A. et al. (2000) Eur. J. Biochem. 267, 1687-97

Tompa P., unpublished observations

Calpain (D. melanogaster)

tr|O96454|

135-227

Tompa, P., unpublished observations

Pp1 reg. sub. (H. sapiens)

tr|O60927

1-126

Zhang J. et al. (1998) Biochemistry 37, 16728-16734

MACS_BOVIN

sp|P12624|

1-331

Manenti S. et al. (1993) J. Biol. Chem. 268, 6878-6881

CAD1_MOUSE

sp|P09803|

734-884

Huber, A. H. et al. (2001) J. Biol. Chem. 276, 12301-9

INVO_HUMAN

sp|P07476|

1-585


Etoh Y. et al. (1986) Biochem. Biophys. Res. Commun. 136, 51-56

Eckert R. L. and Green H. (1986) Cell 46, 583-589

Rice R. H. and Green H. (1984) Cell 18, 681694

HS9A_CHICK

sp|P11501|

227-293

Csermely P. and Tompa, P., unpublished observations

NUP2_YEAST

sp|P32499|

1-720

Denning D. P. et al. (2002) J. Biol. Chem. 277, 33447-33455

Denning D. P. et al. (2002) Proc. Natl. Acad. Sci. USA 100, 2450-2455

DH10_ARATH

sp|P42759|

1-260

Tompa P., unpublsihed observations

CGB1_HUMAN

sp|P14635|

1-121

Cox C. J. et al. (2002) FEBS Lett. 527, 303-308

COA1_SV40

sp|P03087|

299-364

Liddington R. C. et al. (1991) Nature 354, 278-284

ITF2_HUMAN

sp|P15884|

1-131

Knapp S. et al. (2001) J. Mol. Biol. 306, 1179-89

EPN1_RAT

sp|O88339|

144-575

Kalthoff C. et al. (2002) J. Biol. Chem. 277, 8209-8216

A180_MOUSE

sp|Q61548|

328-901

Kalthoff C. et al. (2002) J. Biol. Chem. 277, 8209-8216

IPA3_YEAST

sp|P01094|

1-68

Li M. et al. (2000) Nat. Struct. Biol. 7, 113-117

CAS1_MOUSE

sp|P19228|

16-313

Bhattacharyya, J. and Das, K. P. (1999) J. Biol. Chem. 274, 15505-15509

CASB_HUMAN

sp|P05814|

16-226

Holt C. et al. (1993) J. Chem. Soc. Faraday Trans.89, 2683

Syme C. D. et al. (2002) Eur. J. Biochem. 269, 148

CASK_HUMAN

sp|P07498|

21-182

Holt C. et al. (1993) J. Chem. Soc. Faraday Trans.89, 2683

Syme C. D. et al. (2002) Eur. J. Biochem. 269, 148

4BP1_MOUSE

sp|Q60876|

1-117

Fletcher, C. M. and Wagner, G. (1998) Prot. Sci. 7, 1639-42

IPKA_HUMAN

sp|P61925|

1-75

Hauer, J. A. et al. (1999) Biochemistry 38, 6774-80

Hauer, J. A. et al. (1999) Prot. Sci. 8, 545-53

PRG (H. sapiens)

tr|Q04118|

1-309

Muenzer, J. et al. (1979) J. Biol. Chem. 254, 5629-34

Loomis, R. E. et al. (1985) Int. J. Pept. Prot. Res. 26, 621-629

REGN_LAMBD

sp|P03045|

1-107

Greenblatt J. and Li J. (1982) J. Biol. Chem. 257, 362-5

Van Gilst M. R. and von Hippel, P. H. (1997) J. Mol. Biol. 274, 160-73

CREB_HUMAN

sp|P16220|

4-266

Radhakrishnan, I. et al. (1998) FEBS Lett. 430, 317-22

TTF1 (H. sapiens)

tr|O14956|

1-125

Tell, G. et al. (1998) Biochem. J. 329, 395-403

RLA3_YEAST

sp|P10622|

1-106

Zurdo, J. et al. (2000) Biochemistry 39, 8935-43

CDNC_HUMAN

sp|P49918|

1-316

Adkins, J. N. and Lumb, K. J. (2002) Proteins 46, 1-7

FLIC_SALTY

sp|P06179|

1-66

Gugolya, Z. et al. (2003) FEBS Lett. 535, 66-70

NFH_MOUSE

sp|P19246|

409-1087

Brown, H. G. and Hoh, J. H. (1997) Biochemistry 36, 15035-40

P53_HUMAN

sp|P04637|

1-74

Bell, S. et al. (2002) J. Mol. Biol. 322, 917-27

Dawson, R. et al. (2003) J. Mol. Biol. 332, 1131-41

XPA_XENLA

sp|P27088|

1-85

Iakoucheva, L. M. et al. (2001) Prot. Sci. 10, 560-71

Titin (H. sapiens)

tr|Q8WZ42|

9880-12031

Li, H. et al (2001) Proc. Natl. Acad. Sci. USA 98, 10682-6

Ma, K. and Wang, K. (2003) Biochem J. 374, 687-95

Trombitas, K. et al. (1998) J. Cell. Biol. 140, 853-9

LEA1_APHAV

sp|Q95V77|

1-143

Soulages, J. L. et al. (2002) Plant Physiol. 128, 822-32

Goyal, K. et al. (2003) J. Biol. Chem. 278, 12977-12984

HSF_YEAST

sp|P10961|

1-168

Uversky V. N. et al. (2000) Proteins 41, 415-427

I4G1_HUMAN

sp|Q04637|

589-687

Uversky V. N. et al. (2000) Proteins 41, 415-427

HG17_HUMAN

sp|P05204|

1-89

Uversky V. N. et al. (2000) Proteins 41, 415-427

LEF1_MOUSE

sp|P27782|

296-381

Uversky V. N. et al. (2000) Proteins 41, 415-427

NZFF1 (R. norvegicus)

tr|P70475|

487-608

Uversky V. N. et al. (2000) Proteins 41, 415-427

TOP1_HUMAN

sp|P11387|

1-198

Uversky V. N. et al. (2000) Proteins 41, 415-427

GCR_HUMAN

sp|P04150|

73-263

Uversky V. N. et al. (2000) Proteins 41, 415-427

MAX_FELCA

sp|P61245|

1-160

Uversky V. N. et al. (2000) Proteins 41, 415-427

SEC9_YEAST

sp|P40357|

407-651

Uversky V. N. et al. (2000) Proteins 41, 415-427

SP2D_HUMAN

sp|P22532|

1-72

Uversky V. N. et al. (2000) Proteins 41, 415-427

SdrD ( S. aureus)

tr|O86488|

550-1124

Uversky V. N. et al. (2000) Proteins 41, 415-427

HRP II (P. falciparum)

tr|P90582|

1-309

Uversky V. N. et al. (2000) Proteins 41, 415-427

MBP_BOVIN

sp|P02687|

1-169

Uversky V. N. et al. (2000) Proteins 41, 415-427

PTHR_HUMAN

sp|P12272|

35-177

Uversky V. N. et al. (2000) Proteins 41, 415-427

SPRC_HUMAN

sp|P09486|

18-88

Uversky V. N. et al. (2000) Proteins 41, 415-427

RL2_SHIFL

sp|P60429|

1-272

Uversky V. N. et al. (2000) Proteins 41, 415-427

RL27_ECOLI

sp|P02427|

1-84

Uversky V. N. et al. (2000) Proteins 41, 415-427

RL31_ECOLI

sp|P02432|

1-70

Uversky V. N. et al. (2000) Proteins 41, 415-427

RL32_ECOLI

sp|P02435|

1-56

Uversky V. N. et al. (2000) Proteins 41, 415-427

RL33_ECOLI

sp|P02436|

1-54

Uversky V. N. et al. (2000) Proteins 41, 415-427

RS12_ECOLI

sp|P02367|

1-123

Uversky V. N. et al. (2000) Proteins 41, 415-427

RS18_ECOLI

sp|P02374|

1-74

Uversky V. N. et al. (2000) Proteins 41, 415-427

RS19_ECOLI

sp|P02375|

1-91

Uversky V. N. et al. (2000) Proteins 41, 415-427

RS21_ECOLI

sp|P02379|

1-70

Uversky V. N. et al. (2000) Proteins 41, 415-427

TAF1_DROME

sp|P51123|

11-78

Uversky V. N. et al. (2000) Proteins 41, 415-427

NEF_HV112

sp|P04324|

1-206

Uversky V. N. et al. (2000) Proteins 41, 415-427

SN25_CHICK

sp|P60878|

1-206

Uversky V. N. et al. (2000) Proteins 41, 415-427

TF65_HUMAN

sp|Q04206|

428-551

Uversky V. N. (2002) Prot. sci. 11, 739-756

SUBT_BACAM

sp|P00782|

33-108

Uversky V. N. (2002) Prot. sci. 11, 739-756

Tropomodulin (G. gallus)

tr|Q91006|

1-92

Uversky V. N. (2002) Prot. sci. 11, 739-756

HIS1_HUMAN

sp|P15515|

20-57

Uversky V. N. (2002) Prot. sci. 11, 739-756

AP1_HUMAN

sp|P05412|

257-315

Uversky V. N. (2002) Prot. sci. 11, 739-756

FA39_HUMAN

sp|P49913|

134-170

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

H3T_HUMAN

sp|Q16695|

1-40

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

H5_CHICK

sp|P02259|

101-186

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

RFA1_HUMAN

sp|P27694|

109-169

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

RGS4_RAT

sp|P49799|

1-60

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

CLUS_RAT

sp|P05371|

386-446

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

EFG_THETH

sp|P13551|

401-481

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

GLMT_RAT

sp|P13255|

1-40

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

SYG_THETH

sp|P56206|

95-158

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

DHB1_HUMAN

sp|P14061|

285-327

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

APE1_HUMAN

sp|P27695|

1-41

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

HSP_CHICK

sp|P15340|

1-61

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

COAT_TBSVB

sp|P11795|

1-101

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

MYC_HUMAN

sp|P01106|

1-144

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

Bcl-2 (H. sapiens)

gb |1G5MA|

24-93

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

POLS_SINDO

sp|P27285|

1-106

Dunker A. K. et al. (2002) Biochemistry 41, 6573-6582

Gliotactin (D. melanogaster)

tr|Q9NK80|

750-956

Zeev-Ben-Mordehai T. et al. (2003) Proteins 53, 758-67

Dsp-16

gb |AAA63613.1|

1-155

Lisse, T. et al. (1996) Biol. Chem. 377, 555-61